Stimulating results

TENT-A2 Results Paper

Neuromod has published the results of the company's TENT-A2 (Treatment Evaluation of Neuromodulation for Tinnitus - Stage A2) clinical trial in Nature - Scientific Reports in a paper titled: ‘Different bimodal neuromodulation settings reduce tinnitus symptoms in a large randomized trial’.

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The study is the Neuromod's second large-scale clinical trial conducted in the tinnitus field with 191 enrolled participants, providing further evidence regarding the safety and patient tolerability of bimodal neuromodulation for the treatment of tinnitus while demonstrating greater efficacy of reducing tinnitus symptoms than the first large-scale trial, TENT-A1. 95% of treatment compliant participants reported an improvement in tinnitus symptom severity when evaluated after 12 weeks of treatment, with many experiencing sustained benefit 12 months post-treatment.

TENT-A2 Key Findings

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TENT-A2 Results Paper

Nature - Scientific Reports

The TENT-A2 clinical trial concludes that changing bimodal neuromodulation stimuli, sound and electrical stimulation of the tongue, during a patient's treatment plan can provide greater reduction in tinnitus symptom severity, and therapeutic effects can be sustained for up to 12 months post-treatment.

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The publication of the TENT-A2 results in Nature – Scientific Reports follows on from the publication of the TENT-A1 results as the cover story in Science – Translational Medicine in 2020. This second major publication continues Neuromod’s strategy to establish the clinical credibility of bimodal neuromodulation through publishing large-scale clinical trials in top-tier peer-reviewed journals.